冯美卿生物药物学系,教授,博士生导师,硕士生导师
姓名:冯美卿
职称:教授
电子邮件:fmq@fudan.edu.cn
电话:021-51980035
学历:博士
通讯地址:张衡路826号科研楼225
个人主页:

教育经历

1985.08 – 1990.07  上海医科大学药学院  学士

1996.03 – 1999.03  石油大学(北京)化学工艺系  硕士

2001.09 – 2004.06  永利欢乐娱人城  博士

 

工作经历

1990.07 – 1994.06  河北省药物研究所试验药厂

1994.07 – 2004.11  河北科技大学,化学与制药工程学院

2004.12 – 2014.12  永利欢乐娱人城    副教授

2014.12 – 至今    永利欢乐娱人城   教授


承担科研项目情况

1. 上海市科委重点项目:抗癌药物CK-和蛋白激酶用于肝癌诊断中的子课题微生物转化法制备抗癌药物CK,(054319927)子课题负责人, 2005-2007

2. 国家自然基金项目:人参稀有皂甙微生物转化机制(途径)及代谢调节(30772676)2008-2010

3. 国家自然基金项目:重组HDL-药物复合物肝靶向性及其分子机制研究(30973684)2010年-2012年,

4. 国家自然基金项目:载脂蛋白AI介导小干扰RNA靶向至肝脏的相关机制及抗HBV作用研究(81341083)2014-2015

5. 上海市纳米专项课题载脂蛋白A-I介导的重组HDL纳米粒肝靶向性及其机制研究(0952nm03500),2009-2011。

6. 上海市科委重点项目毕赤酵母表达人载脂蛋白A-I抗动脉粥样硬化成药性研究(12431900202)2012-2015

7. 973项目肺癌在体分子分型的新型纳米分子成像探针基础研究(骨干(2015CB931800) 2015-2019


获奖及荣誉

上海市科委科技进步   二等奖  排名第二

上海市药学会科技进步  三等奖  排名第二


研究方向

1. 基因工程技术药物研发及应用

2. 天然产物为生物转化研究


社会任职

2010.05 – 现在  上海药学会抗生素分会理事


代表性论著

1.Zhu HaiYan, Han Lei, et al, Feng Meiqing*. Baicalin Inhibits Autophagy Induced by Influenza A Virus H3N2. Antiviral Research. 2015; 113: 62-70.


2.Wang baolong Han Lei, et al, Feng Meiqing*. Combination of ApoA1 Modified Liposome-doxorubicin with Autophagy Inhibitors Overcame Drug resistance in Vitro. Pharmaceutical Sciences. 2014; 103:3994–4004.


3.Meiqing Feng, Ziwei Liao, Lei Han, Jiyang Li & Li Ye. Enhancement of microbial hydroxylation of 13-ethyl-gon-4-ene-3,17-dione  by Metarhiziumanisopliae using anoliposome technique. Journal of Industrial Microbiology & Biotechnology. 2014; 41:619-627.


4.Li Ye, Jiajun Fan, et al, Meiqing Feng*, DianwenJu*. Tumor Necrosis Therapy Antibody Interleukin-2 Fusion  Protein Elicits Prolonged and Targeted Antitumor Effects in vivo. Appl Microbiol Biotechnol. 2014; 98:4053–4061.


5.Jiajun Fan, Xian Zeng, Yubin Li, Shaofei Wang, Ziyu Wang, Yun Sun, MeiqingFeng*, DianwenJu*. Autophagy Plays a Critical Role in ChLym-1-Induced Cytotoxicity of Non-Hodgkin’s Lymphoma Cells. Plos One. doi:10.1371/journal.pone.0072478.


6.Baolong Wan ,Yuan Yuan, Lei Han, and Meiqing Feng*. Recombinant lipoproteins reinforce cytotoxicity of doxorubicin to hepatocellular carcinoma. J Drug Target, 2014; 22(1): 76–85.


7.Weina Wang, Wei Zhou, Baolong Wang, Haiyan Zhu, Meiqing Feng*. Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits. Acta Biochimica et Biophysica Sinica. 2013; 45: 95–103.


8.Weina Wang, Xunlong Shi, Yuan Yuan, Haiyan Zhu, Wei Zhou, Hai Huang, and Meiqing Feng*. Inhibitory effect of apolipoprotein A-I on matrix metalloproteinase-2 expression in vivo and in vitro. Acta Biochim Biophys Sin. 2013; 45: 194–202.


9.Yuan Yuan, Weina Wang, Baolong Wang, Haiyan Zhu, Boheng Zhang, and Meiqing Feng*. Delivery of hydrophilic drug doxorubicin hydrochloride targeted liver using apoAI as carrier. Journal of Drug of Targeting. 2013.21(4): 367–374.


10.Li Ye, Chunyan Zhang, Jiyang Li, Xunlong Shi and Meiqing Feng*. Effects of external calcium on the biotransformation of ginsenoside Rb1 to ginsenoside Rd by Paecilomycesbainier 229-7. World J Microbiol Biotechnol. 2012 (28): 857–863.


11.Yang Ding, Wei Wang, Meiqing Feng*, Jianping Zhou*. A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy. Biomaterials. 2012 (33): 8893-8905.


12.Qin Yan, Wei Zhou, XunLong Shi, Pei Zhou, Dianwen Ju, Meiqing Feng*. Biotransformation pathways of ginsenoside Rb1 to compound K by_-glucosidases in fungus PaecilomycesBainier sp. 229. Process Biochemistry. 2010; 45: 1550–1556.


13.Li Ye, Chao-Qun Zhou, Wei Zhou, Pei Zhou, Dao-Feng Chen, Xiao-Hui Liu, Xun-Long Shi, Meiqing Feng*. Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate tolerant Paecilomycesbainier 229-7. Bioresource Technology. 2010; 101: 7872–7876.


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